Publication of New Article

We are pleased to announce the publication of a new article in Biology & Molecular Medicine,

Durable Remission in BRCA2-Mutated, PD-L1–Overexpressing Pancreatic Cancer with Multimodal Precision Therapy: A Case Report
Christina Bogdani, Anita Karimi, Despina Siolas M.D. Ph.D.

This case report describes a 60-year-old man with pancreatic ductal adenocarcinoma (PDAC) and a pathogenic germline BRCA2 mutation who received modified FOLFIRINOX plus losartan with stereotactic body radiation therapy (SBRT) and nivolumab prior to distal pancreatectomy and splenectomy. Surveillance imaging later detected a solitary liver metastasis with PD-L1 combined positive score (CPS) = 100, which was treated with percutaneous microwave ablation, after which the patient began maintenance therapy with olaparib and pembrolizumab. The patient remains in clinical remission more than five years after detection of the liver metastasis, with no evidence of disease on serial MRI and PET/CT imaging.

The full article is available online and can be accessed through the journal website:
Durable Remission in BRCA2-Mutated, PD-L1–Overexpressing Pancreatic Cancer with Multimodal Precision Therapy: A Case Report | Biology & Molecular Medicine